The 49ers have not won a game in Minneapolis since 1990. That didn't change on Monday night, as the Vikings pulled out a 22-17 victory at home on "Monday Night Football."The Vikings got out to an early lead, and the 49ers found themselves playing catch-up all game long. Despite cutting the deficit down to five twice in the contest, San Francisco was unable to claw its way back, dropping its seventh consecutive game in Minnesota.Quarterback Kirk Cousins was excellent for Kevin O'Connell's crew, even without star wide receiver Justin Jefferson, who is sidelined with a hamstring injury Ben Gamel Jersey . The Minnesota signal caller threw for 378 yards, two touchdowns and an interception to improve to 3-4 on the year.In Jefferson's absence, rookie WR Jordan Addison and TE T.J. Hockenson stepped up in the pa sing game. Addison hauled in seven catches for 123 yards and two touchdowns, including a 60-yard TD to end the first half. Hockenson brought in 11 catches for 86 yards. The offensive line was arguably the biggest factor of the day, as the Minnesota unit did not allow a single sack all day.San Francisco dropped to 5-2, losing its second-straight game after the lo s to Cleveland last week. The offense was unable to make up for the absence of wide receiver Deebo Samuel, who was out with a hamstring injury. Quarterback Brock Purdy threw for 272 yards, but only found the end zone once and was picked off twice.Both of those interceptions were by Vikings cornerback Camryn Bynum, who shined on defense. He led all Minnesota defenders with nine total tackles, seven solo tackles, two pa s deflections and the two interceptions.MORE:The Sporting News tracked live updates and highlights throughout the "Monday Night Football" matchup between the 49ers and Vikings.1234Final49ers077317Vikings796022Final: Vikings 22, 49ers 1711:10 p.m. Interception!Bynum comes up with his second pick of the night, grabbing a Purdy attempt to McCloud. The cornerback leapt up for a great catch to seal the victory. That's going to do it in this one, as the Vikings will hold on for the win. That's a big victory for Minnesota, improving to 3-4, while San Francisco dropped its second game in a row, falling to 5-2.Bynum picks it off again to seal the W! NFL (@NFL) 11:09 p.m. Purdy connects with Ray-Ray McCloud for 11 yards and gets the ball down to the Minnesota 40. The 49ers uses their first timeout to stop the clock with 35 seconds.11:07 p.m. Mi sed field goal!Joseph's 50 yard attempt kept pushing to the right, and leans just enough to mi s the uprights. Now, the 49ers get the ball at their own 40-yard line with 1:11 left, with no timeouts.11:06 p.m. Minnesota plays it safe and calls a run, gaining four yards, which is short of a first time. O'Connell lets the clock run until 1:16 and calls a timeout. The Vikings coach is electing to go up by eight instead of icing the game with a potential first down.11:03 p.m. The two minute warning hits in Minneapolis. This could be the game on the next play. The Vikings have third-and-10, but the 49ers are out of timeouts. A first down would e sentially seal a home win for Cousins and Co.11:01 p.m. Cousins come through on arguably the biggest play of the day. On third-and-3, the Vikings QB sidesteps around pre sure and drops a dime to Addison for the first down with 2:16 left. After a failed Minnesota run goes for negative yards, San Francisco calls its final timeout.10:53 p.m. Interception!Purdy lofts one way in front of Jennings and it's picked off by Camryn Bynum. It looks the 49ers QB just lost control of that one, as there was no short for the receiver to get it. That's a back-breaking turnover for the 49ers to give up with 5:30 to go.Camryn Bynum picks off Purdy!: on ESPN/ABC: Stream on NFL (@NFL) 10:52 p.m. Purdy's second sneak attempt works, picking up two yards to move the chain.10:50 p.m. After a 16-yard completion to Kittle, McCaffrey picks up nine yards on the ground. However, McCafrey and Purdy are stopped on their second and third down attempts, and it's fourth down for the Niners. Kyle Shanahan keeps the offense out on the field needing a yard.10:47 p.m. On third-and-four at the San Francisco 42, Osborn can't come up with the reception on a deep ball, losing control as he's fell to the ground. Despite the field position, O'Connell elects to punt it away instead of going for it on fourth down with 9:14 left. That's an uncharacteristic move for the usually aggre sive O'Connell.10:44 p.m. Powell makes a heck of a play on third down, coming back to dive for a low ball that was good for a first down. He follows it up with another reception right after that goes for 12 yards.10:43 p.m. Greenlaw returns after mi sing a play. It's third-and-7 for the Vikings at their own 40-yard line.10:41 p.m. On the second play of the Vikings drive, 49ers linebacker Dre Greenlaw goes down after tackling Mattison on a run. After a couple moments on the ground, he was able to get up and jog to the sidelines. Greenlaw mi sed last week with a hamstring injury.Vikings 22, 49ers 1710:36 p.m. Field goal!That's how to regain your confidence. After mi sing his earlier attempt, Moody nails a 55-yard field goal to cut the deficit back to five.10:35 p.m. Aiyuk and the 49ers think they have a conversion on third down. Purdy scrambles out of the pocket and throws acro s his body to his receiver, but Aiyuk is unable to pick the ball up before hitting the ground. Jake Moody is coming out for a long field goal.End of the third quarter: Vikings 22, 49ers 1410:29 p.m. The third quarter ends with the 49ers having second-and-1 at their own 41. The Vikings take an eight-point lead into the final 15 minutes of regulation.Vikings 22, 49ers 1410:28 p.m. Field goal!Joseph hits his third field goal tonight, this one a booming 54-yarder, making it an eight-point game with 20 seconds left in the third.10:27 p.m. The Vikings can't convert on third-and-5, and are bringing out Joseph for a long-range field goal.10:26 p.m. Addison is heading down to the locker room after walking off on his own. If he can't return, that's a brutal blow to a Minnesota wide receiver group already without star Justin Jefferson.10:24 p.m. Now Addison is down after an incomplete pa s. He and Ward got tied up Jay Bruce Jersey and the rookie is staying down on the sidelines. As the staff continues to check on Addison, Hockenson comes back in, a good sign for Minnesota.10:19 p.m. Cousin hits Hockenson for 10 yards, and then Chandler for 12 to get the ball to the San Francisco 45. Hockenson was tackled from behind while blocking for Chandler, and he's down on the turf again, grabbing towards his calf//ankle.10:17 p.m. Cousins has been money on third down tonight and he does it again, this time finding Powell on third-and-5 for a pickup of 16. He is 8-for-8 on throws 10 or more yards down the field.Vikings 19, 49ers 1410:09 p.m. Touchdown!The Vikings dial up a blitz that leaves McCaffrey wide open for a screen, and he sprints 35 yards to the house. Purdy and Co. need just three plays to answer the Vikings' field goal with a touchdown. It's down to a five-point game with 5:54 left in the third.CMC has another to bring it back to a one-score game.: on ESPN/ABC: Stream on NFL (@NFL) 10:08 p.m. San Francisco wastes no time getting down field, as a 12-yard run by McCaffrey is followed by a 28-yard completion to Kittle, getting the 49ers to the Vikings' 35-yard line.Vikings 19, 49ers 710:05 p.m. Field goal! Joseph's 20-yard attempt goes through the uprights. That is now twice Minnesota has settled for short field goals rather than go for it on fourth down in the red zone.10:04 p.m. The penalty on Bradbury proves costly, as the Vikings fail to get into the end zone, and on fourth down, O'Connell calls for the field goal unit.10:02 p.m. After a failed QB sneak on first down, center Garrett Bradbury is called for a false start, and that will push Minnesota back five yards.FRED WARNER OFF THE TOP ROPE!: on ESPN/ABC: Stream on NFL (@NFL) 10:01 p.m. A penalty on Deommodore Lenoir in the end zone brings the ball down to the one-yard line. There wasn't a ton of grabbing from Lenoir on Addison, but it was enough for a flag.9:59 p.m. The Vikings continue to carve through this 49ers' secondary, as this time, Cousins connects with Brandon Powell for a gain of 27 yards. Minnesota has the ball in the red zone, threatening to extend the lead further.9:57 p.m. Minnesota's first offensive play of the second half is an 18-yard completion to K.J. Osborn. Two plays later, Cousins hits Addison for 11 yards, bringing the line of scrimmage to the San Francisco 45.9:51 p.m. Purdy's pa s is blocked on third-and-25, and San Francisco will have to punt for the first time tonight.9:50 p.m. Purdy tries to throw the ball away while being pre sured by Danielle Hunter, but it's ruled a fumble and recovery by the Vikings. However, after review, it was ruled he was down before losing control. It's a lo s of 15 and brings up a long third down for San Francisco.9:46 p.m. Kittle takes a carry on third-and-1 and the tight end gets two yards needed to move the chains.9:44 p.m. The second half is underway in Minneapolis. San Francisco gets the ball to start the third quarter.End of Jean Segura Jersey first half: Vikings 16, 49ers 7Vikings 16, 49ers 79:27 p.m. Touchdown!Jordan Addison had the ball ripped out of his hands by Charvarius Ward earlier in the game for an interception. He returns the favor with seven seconds left in the second half and breaks away for a 60-yard touchdown on third down. Joseph mi ses the extra point, so it's only six points on the board. Just as it seemed like the 49ers had swung momentum a bit, the Vikings snag it right back before half.TAKEN AWAY BY ADDISON FOR THE 60-YARD SCORE : on ESPN/ABC: Stream on NFL (@NFL) Jordan Addison: : on ESPN/ABC: Stream on NFL (@NFL) 9:25 p.m. Hockenson is back after that bizarre sequence earlier in the quarter with O'Connell.Vikings 10, 49ers 79:20 p.m. Touchdown!The first attempt doesn't go, but McCaffrey rumbles in on second-and-goal to get the 49ers on the board. A strong drive from Purdy and Co. to close out what has been a le s than stellar first half for the offense. McCaffrey's TD streak is now up to 16, breaking the record for most consecutive games with a score.16th straight game with a scrimmage TD for , an NFL record! : on ESPN/ABC: Stream on NFL (@NFL) 9:18 p.m. Ro s Dwelley takes a short pa s and barrels down to the Minnesota 6-yard line. The Vikings take a timeout with 1:08 remaining, looking to get the ball back before the half ends while the 49ers are trying to get on the board for the first time.9:13 p.m. The two minute warning hits with the 49ers in need of another yard on third down. San Francisco has the ball at the Minnesota 26, looking to get its first points of the game.9:11 p.m. McCaffrey is given the nod on third-and-1, and he gets enough for the first. The San Francisco running back hasn't been a major factor yet.9:09 p.m. A penalty pushes the 49ers back from third-and-2 to third-and-7, but that doesn't matter for Purdy. The 49ers QB finds Brandon Aiyuk over the middle on a post route for the first down and more, picking up 25 yards.Vikings 10, 49ers 09:03 p.m. Field goal!Greg Joseph sinks the 21-yard field goal, and Minnesota extends its lead to two scores with 7:33 left in the half.9:02 p.m. The Vikings get third-and-goal, but an Alexander Mattison one-yard run is followed by Cousins throwing two incompletions, and the team has to settle for a field goal.8:58 p.m. Hockenson went down after the play, grabbing at his calf. It appeared Kevin O'Connell told him to stay down, so something to monitor. The tight end has been great so far tonight.Vikings coach Kevin OConnell telling TJ Hockenson to go down lol Tedd Buddwell (@TedBuddy8) 8:57 p.m. Cam Akers takes a screen pa s and races down to the San Francisco three-yard line. The 49ers were blitzing, and Cousin timed it perfectly for the big gain.8:55 p.m. Minnesota breaking out the creativity. The Vikings execute a double pa s, with Cousins pa sing to Addison, who pa sed to Ty Chandler for a gain of over 20. However, offensive pa s interference brings the play back.8:52 p.m. Another catch for Hockenson that picks up a first down. The tight end is up to five catches already, as he's very clearly Cousin's No. 1 target tonight. Minnesota is into San Francisco territory, moving the chains to the 46-yard line.8:47 p.m. Mi sed field goal!Moody's attempt from 40 yards trails too far to the right and mi ses. One week after mi sing a 41-yard attempt for the win last week, the 49ers kickers puts up an errant kick from similar distance tonight. The Vikings' lead remains at seven.8:46 p.m. On third down, Jennings slips as he turns and he's unable to come up with the grab. Jake Moody will come out for the field goal attempt.End of the first quarter: Vikings 7, 49ers8:44 p.m. The first quarter comes to a close with the 49ers at the Vikings' 22. It'll be third down once they flip sides.8:42 p.m. Purdy doesn't show off the wheels often, but he does on second-and-10, picking up 17 yards with his legs. San Francisco is threatening with the ball at the Minnesota 26.. making magic happen : on ESPN/ABC: Stream on NFL (@NFL) 8:40 p.m. The 49ers respond to the Vikings' score with a solid drive of their own, as they have worked their way into Minnesota territory. An 18-yard completion to Juaun Jennings helped San Francisco cro s midfield.Vikings 7, 49ers 08:33 p.m. Touchdown!Cousins drops a deep dime on third-and-2 that finds Jordan Addison for a 20-yard touchdown. After the pick, the offense responds by going 89 yards to the end zone. Interesting note the Vikings are the first team this season to Robinson Cano Jersey score before the 49ers.Vikings cap an 89-yard drive with a Jordan Addison touchdown!: on ESPN/ABC: Stream on NFL (@NFL) 8:30 p.m. The Vikings get to the 50-yard line, and then Hockenson comes through again with a big catch, this time for 22 yards to move the chains down to the 49ers' 28-yard line.You have to throw to on . Its the rule.: on ESPN/ABC: Stream on NFL (@NFL) 8:27 p.m. T.J. Hockenson led all Minnesota receivers last week in catches and yards. He and Cousins connect early in this one, with his first catch coming on third-and-12 for a gain of 16 yards.8:22 p.m. Fumble!Vikings' Camryn Bynum punches the ball out of the hands of Christian McCaffrey in the red zone and Minnesota comes up with po se sion. McCaffrey lost control right around the 12-yard line, just moments after the Vikings gave the ball to the 49ers. Each side has a turnover and it's not even four minutes into the game.Vikings respond with a big play on defense : on ESPN/ABC: Stream on NFL (@NFL) 8:18 p.m. Interception!Well that didn't take long. On the third play of the drive, Kirk Cousins throws to Jordan Addison on a slant, but Charvarius Ward literally wrestles it out of the rookie's hands for the pick. The turnovers continue to be a problem for Minnesota. San Francisco takes over po se sion just 1:19 into the game, with great field position no le s.Charvarius Ward said gimme that : on ESPN/ABC: Stream on NFL (@NFL) . took it away : on ESPN/ABC: Stream on NFL (@NFL) 8:15 p.m. The kickoff is away and 49ers vs. Vikings is set to go. Minnesota starts with the ball at its own 25.Pregame7:43 p.m. In a week marred by injuries for the 49ers, they did get good news in the health department this week with the return of Dre Greenlaw. The linebacker mi sed Week 6 with a hamstring injury and was listed as questionable, but is active tonight for San Francisco.7:28 p.m. The 49ers' lo s last week to the Browns was the first time Brock Purdy had lost an NFL game in which he finished. His only other defeat was the 2022 NFC Championship when he tore the UCL in his elbow in first quarter. So this is the first chance for the second-year QB to bounce back after a lo s the week prior.7:14 p.m. Last week, the pa sing game wasn't nearly as effective for the Vikings in the absence of star Justin Jefferson. Kirk Cousins' 181 yards were the second-lowest in Domingo Santana Jersey a single game this season, finding the end zone just once against the Bears. He had thrown at least 2 TDs in every game in 2023 before then.7:09 p.m. 49ers punterJake Moody had a chance for the win last week from 41 yards out and mi sed against the Browns. He's aiming it up tonight ahead of the game from the same distance.Jake Moody, after mi sing a 41-yard potential winning field goal last game, visualizes it goes better from that distance here in Minnesota, 2.5 hours before vs Cam Inman (@CamInman) 7:01 p.m. Here are tonight's inactives. As expected, no Williams or Samuel on the San Francisco side, but McCaffrey is a go. On the Minnesota side, Jefferson, who is on injured reserve, is out a second consecutive week.Tonight's inactives Minnesota Vikings (@Vikings) 6:48 p.m. San Francisco may have won the last two times playing Minnesota, however, home field advantage is real for the Vikings when it comes to this matchup. The last six 49ers-Vikings games to be played in Minneapolis have all resulted in wins for the home side. San Francisco has not won in Minnesota since 1990.6:30 p.m. The 49ers were hit with injuries last week. There won't be Deebo Samuel or Trent Williams tonight, however, San Francisco is expecting Christian McCaffrey to suit up and be available against the Vikings."Christian McCaffrey is gonna be out there tonight but he didn't take a hit in practice all week long..Trent Williams isn't gonna play tonight for the 49ers" ~ Pat McAfee (@PatMcAfeeShow) Date:Monday, Oct. 23Time:8:15 p.m. ET | 7:15 p.m. MT | 5:15 p.m. PT49ers vs. Vikings is set to kick off at 8:15 p.m. ET at U.S. Bank Stadium in Minneapolis, Minn., for "Monday Night Football."The game kicks off at 7:15 p.m. local time, 5:15 time in California.TV channel:ESPNLive stream:ESPN+, | Joe Buck and Troy Aikman will be on the call for 49ers vs. Vikings, with Lisa Salters providing sideline reports for the matchup.The Manningcast is another option for fans, as viewers can follow along with the action with Peyton and Eli Manning. That alternate broadcast is on ESPN2.For cord-cutters, carries the ESPN family of networks, as well as ABC, CBS, Fox, NBC and NFL Network, meaning you will be able to catch nationally televised games throughout the 2023 season. Viewers in Canada can catch the matchup on , which carries NFL Game Pa s.